Original Publication
Open Access

Simulation of Neutropenic Fever/Sepsis

Published: March 15, 2011 | 10.15766/mep_2374-8265.8490

Included in this publication:

  • Simulator Case Neutropenic Fever.doc
  • Case Stem.doc
  • Instructor's Guide Neutropenic Fever.doc
  • Labs And Studies.doc

To view all publication components, extract (i.e., unzip) them from the downloaded .zip file.

Editor's Note: This publication predates our implementation of the Educational Summary Report in 2016 and thus displays a different format than newer publications.


This resource is a simulation case featuring a patient who recently underwent a bone marrow transplant for acute leukemia and then developed neutropenic fever and rapidly evolving sepsis. The module is designed to instruct learners on how to identify the presenting signs of neutropenic fever, the initial management of neutropenic fever, the management of sepsis and septic shock, and the management of pulseless electrical activity arrest. Due to time constraints, the case progresses rapidly from a relatively stable patient to a code. However, this emphasizes the severity of sepsis, particularly in an immunocompromised patient. If personnel resources are available, the learner can also practice delivering bad news to a family member. Mannequin-based simulation cases are becoming much more common in the training of medical residents. Many of these focus on critical care or procedure-based scenarios. While this case is similar in that regard, it has the added element of having the learner deliver bad news to a family member. This communication training can be an additional piece of a curriculum on end-of-life care.

Educational Objectives

By the end of this simulation, learners will be able to:

  1. Identify the early presenting signs of neutropenic fever.
  2. Appropriately manage neutropenic fever and sepsis/septic shock, particularly in regard to antibiotics, fluid management, and vasopressor use.
  3. Provide advanced cardiac life support for pulseless electrical activity.
  4. Deliver bad news to a patient’s family.

Author Information

  • Edward Lee: Internal Medicine Chief Resident, University of California, Los Angeles David Geffen School of Medicine
  • Jason Napolitano: Assistant Clinical Professor, UCLA

None to report.

None to report.


Lee E, Napolitano J. Simulation of neutropenic fever/sepsis. MedEdPORTAL. 2011;7:8490. https://doi.org/10.15766/mep_2374-8265.8490