Introduction: Our understanding of human genetic variation has deepened through the Human Genome and International HapMap projects, which gave us a high-resolution view of human genetic variation and ancestry. Applying this knowledge to the evaluation of ancestry-based genetic testing strategies, such as direct-to-consumer genetic testing, is an important component of the practice of culturally component medicine and a clinically relevant way to teach the foundations of population genetics. This population genetics interactive case discussion was created to emphasize the clinical relevance of population genetics as applied to a required flipped classroom module in the first-year medical genetics course for medical students. Methods: A flipped classroom is an innovative model of learning that inverts the traditional teaching model by delivering didactic content through educational technology prior to the traditional lecture time slot and focusing class time on active exercises and higher-order concept mastery. These facilitate deeper learning of the material and allow students to have more control over their learning. Results: This exercise was first implemented in the required first-year medical genetics course at Boston University School of Medicine in Spring 2013. The Office of Medical Education asked the 180 students whether they agreed this case discussion facilitated learning of the material. The result was an average of 3.5 on a 5-point scale, with 5 being strongly agree. Discussion: This feedback support the idea that the students were interested in the clinical implications of the human genome project data and that this was appropriately related to the practice of culturally component medicine.
- Illustrate how historical human migration patterns have contributed to genetic variation observed in modern populations.
- Differentiate between population subgroups defined by racial categories or geographic ancestry in terms of genetic variation.
- Use the principles of population genetics (e.g., founder effect, Hardy-Weinberg equilibrium, selection pressure) to predict frequencies of alleles and genotypes in a given population.
- Evaluate the significance of identifying the presence of disease alleles on the healthcare system and on individuals acquiring this information directly, in the absence of the guidance of a health care professional.
- Assess the implications of evolving genetic testing technologies on yielding false negative results and the validity of the duty to re-contact concept.
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