An Animation-enhanced Presentation for Illustrating Hormonal and Metabolite Regulation of Metabolic Pathways in the Context of Diabetes

Publication ID Published Volume
9661 January 10, 2014 10


A Microsoft PowerPoint unscripted presentation enhanced with animations that is designed to illustrate the role of insulin, glucagon, cortisol, epinephrine and AMPK along with selected metabolites in regulating specific steps in glycogenesis, glycogenolysis, glycolysis, gluconeogenesis, lipogenesis and lipolysis. The submission is designed to fit within a 90- to 105-minute session with one or two short breaks. A series of slides are used to discuss individual hormones followed by a slide containing all of the hormonal and metabolites effects. Notes are provided for each slide of the presentation containing information that may be incorporated into the narrative or used by the students without discussion during the presentation. A series of impact slides reiterate the effects of insulin deficiency on each metabolic pathway and a final summary slide contains questions that focus on the key hormones, metabolites, enzymes, and tissues.

The submission contains a Microsoft PowerPoint file that contains the presentation and can be modified and updated as appropriate. A DeltaGraph file contains data used to construct the glucose homeostasis graph that appears in the presentation and can be modified for future use. There is also a jpg of the data for individuals lacking the DeltaGraph application.

The curriculum at Southern Illinois University School of Medicine is an integration of basic and clinical sciences using an organ systems approach to introducing topics important to the education and training of medical students. The core of our organization centers around small group discussions of patient problems with optional resource sessions (lectures) that complement the self-directed learning of the students. This animation is used after the students have completed a patient case involving a man with a known history of diabetes (type 2) and alcoholism for which he is non-adherent with his medications and abstinence from drinking ethanol. Because a complete narrative is not provided, its content may be changed depending on the objectives of the curriculum. Discussion of the topic takes between 90 and 115 minutes, which leaves sufficient time for questions during and after the session. The presentation has been used and evaluated over a period of four years with consistent numerical scores. Ratings were strongly agree, agree, disagree and strongly disagree of the following categories: the sessions provided a helpful supplement to my self-directed learning on the cases; sufficient time was scheduled to cover the topics; and the session should be scheduled for future classes. For 2010, 44 SA, 22 A, 3 D and 0 SD; 2011, 36 SA, 27 A, 8 D and 1 SD; 2012, 45 SA, 30 A, 6 D and 3 SD; and 2013, 42 SA, 13 A, 5 D and 0 SD.

Written comments from 2010 were very positive, but there were two consecutive years (2011-2012) of comments suggesting that the slides contained too much information (too many hormones put together). As a result, the presentation was modified in 2013 to break out separate slides containing individual hormones and a composite slide with all the hormones for each metabolic pathway. Specific comments were solicited from the students to address this change. The consensus comment was that the presentation was very helpful and providing separate slides of the role of insulin and glucagon in individual pathways was very much appreciated.


Niederhoffer E. An animation-enhanced presentation for illustrating hormonal and metabolite regulation of metabolic pathways in the context of diabetes. MedEdPORTAL Publications. 2014;10:9661.

Contains Information Suitable for Patient Education

Educational Objectives

  1. To summarize problems associated with glucose homeostasis.
  2. To provide tissue distribution of metabolic pathways.
  3. To detail selected steps in metabolic pathways subject to hormonal and metabolite regulation.
  4. To highlight cellular location of metabolic pathways.
  5. To focus on the impact of insulin deficiency on metabolic pathways.
  6. To provide clinical impact of diabetes.
  7. To summarize classes of medication used to treat problems associated with glucose homeostasis.


  • Biochemical Pathways, Diabetes, Glycolysis, Gluconeogenesis, Glycogenesis, Glycogenolysis, Lipogenesis, Lipolysis, Citric Acid Cycle, Regulation, Social Control, Formal, Insulin, Glucagon, Epinephrine, Cortisol, Hydrocortisone, Glucose, Metabolism, Animation, PowerPoint

Material Access

Please sign in to access this material.

Please register for an AAMC account if you do not have one.


  • Contact Us

ISSN 2374-8265